If you need a powerful message proving that childhood might not be the greatest thing in life, try the documentary titled "Children of the Pyre".

2021.12.08 10:11 JesterRaiin If you need a powerful message proving that childhood might not be the greatest thing in life, try the documentary titled "Children of the Pyre".

If you need a powerful message proving that childhood might not be the greatest thing in life, try the documentary titled submitted by JesterRaiin to antinatalism [link] [comments]


2021.12.08 10:11 Big_TCamp 2 phenos of Super Lemon Haze. About 8-10 days till harvest.

2 phenos of Super Lemon Haze. About 8-10 days till harvest. submitted by Big_TCamp to weed [link] [comments]


2021.12.08 10:11 ShortAlgo $EIX Awaiting Short Signal. Stock Trading Ideas by UltraAlgo.com

$EIX Awaiting Short Signal. Stock Trading Ideas by UltraAlgo.com submitted by ShortAlgo to UltraAlgo [link] [comments]


2021.12.08 10:11 SnooDucks7364 02. ELASTIC - "Pornboost"

02. ELASTIC - submitted by SnooDucks7364 to OldSkoolTekMuZik [link] [comments]


2021.12.08 10:11 YeetoCheetoNeeto The hilarious contradiction between the church’s “members” and “leadership”

I mean don’t get me wrong, the prophet and apostles etc I am NOT a fan of, but them supporting vaccinations is appreciative of me as a healthcare worker
And yet most of the congregation are antivaxxers and “take it up with God” even though the prophet told them several time to be vaccinated and mask.
Now that I’ve seen this hypocrisy I’ve finally solidified that members are members to benefit themselves and their shitty beliefs and not for the “Gospel” or whatever the fuck it is
submitted by YeetoCheetoNeeto to exmormon [link] [comments]


2021.12.08 10:11 Necessary_Author_308 🔥 TETHER HERO🔥 | 8th Presale P2E game | NFT project on BSC | Metaverse Bsc Project | Experienced Team | USDT rewards pool | Experienced Marketing Team

🔥 TETHER HERO🔥
🤩A cool P2E game + NFT project+Metaverse on BSC.
🦸‍♂️Tether Hero- Dark City is an upcoming Play-to-earn game of the addictive battle Genre.Players will venture to explore the dark City chaotic Alien world.
⚔️ Mystery boxs -getting different Humans/Alien/Monster roles.
⚔️ Adventure mode - fight in Dark City against bosses.
⚔️ Stake NFT Cards - in staking section to select lock period and earn money .
⚔️ Trade NFT Cards - listing your NFT card for sale or purchase others.
⚔️ Earn USDT- Play game which pay in USDT
💰BIG USDT Rewards Pool
💹 Aggressive marketing push
🎥 AMAs for the communities
✅Doxxed Devs
🔒Liquidity locked
🛡KYC& Audit Done
⭐️Binance Smart Chain/Pancakeswap
⭐️Token symbols:USDH
💛 Soft Cap:400 BNB
Hard Cap: 800 BNB
Min: 0.2BNB
Max. :2.5BNB
⏰PRESALE TIME : 08 DEC | 15:00 UTC
🚀 LAUNCH TIME: 1 HOUR AFTER PRESALE
💕PRESALE FLATFORM:PINKSALE
✔️Tech-Audit
🏷️ Contract Address: 0xF7F702237f71437537d4a155a32Fa82602F26F3b
🍰 Pancakeswap:https://pancakeswap.finance/swap?outputCurrency=0xF7F702237f71437537d4a155a32Fa82602F26F3b
🔹 Renounced Ownership: https://bscscan.com/token/0xF7F702237f71437537d4a155a32Fa82602F26F3b#readContract
🔐 Liquidity Lock 1 YEAR : https://deeplock.io/lock/0x5ce0abf98b304d556cce849fe39538dbf58c6db3
submitted by Necessary_Author_308 to cryptostreetbets [link] [comments]


2021.12.08 10:11 mike0491 Vinicius HAS won potm but 87 rated.

Shows that totgs not counting this year towards rating. Expected Friday.
submitted by mike0491 to FIFA [link] [comments]


2021.12.08 10:11 pistol_creek What is something special from the you live Billy Strings show that doesn’t come through on the live recordings?

I was at the Renewal festival in Buena Vista right up in the front. One thing I though was so awesome was how you could literally feel Royal’s bass thumping through your body. When they would transition from a traditional bluegrass jam into more of a space section, royal would let a big note ring, Billy would trigger his effects, and you could feel that coursing through your body. Super cool.
submitted by pistol_creek to BillyStrings [link] [comments]


2021.12.08 10:11 ShortAlgo $DLTH Awaiting Short Signal. Stock Trading Ideas by UltraAlgo.com

$DLTH Awaiting Short Signal. Stock Trading Ideas by UltraAlgo.com submitted by ShortAlgo to UltraAlgo [link] [comments]


2021.12.08 10:11 InsertRedditUname Large overgrown island in the yard- What would you do?

We're closing on a house Friday, in the Northeast zone 6B. We have 1.7 acres on the side of a hill. The area pictured is on a slope and has a stacked stone wall around it. below it is flat yard with grass.
The walled-in "island" is @ 2000Ft'+ and overgrown. Lots of possibilities. My initial thought was to pull everything out, lay a stone path, and plant native plants in sections or doing a massive wildflower garden.
Your ideas most welcome!
submitted by InsertRedditUname to landscaping [link] [comments]


2021.12.08 10:11 Nikand262 But...He didn't do anything.

But...He didn't do anything. submitted by Nikand262 to memes [link] [comments]


2021.12.08 10:11 7di7di Strub

Strub submitted by 7di7di to infoforeverything [link] [comments]


2021.12.08 10:11 JC40main If you had an war scheduled during the downtime attackers auto won, lost WW

Title says it all, woke up to an green Windsward on Oceana this morning, 1 of the largest and diverse faction map is now basically all green, awesome.......
submitted by JC40main to newworldgame [link] [comments]


2021.12.08 10:11 ShortAlgo $SONY Awaiting Short Signal. Stock Trading Ideas by UltraAlgo.com

$SONY Awaiting Short Signal. Stock Trading Ideas by UltraAlgo.com submitted by ShortAlgo to UltraAlgo [link] [comments]


2021.12.08 10:11 JustLeafy2003 From a PhD Thesis I found

Metformin, also known as 1,1-dimethylbiguanide hydrochloride is nowadays the most frequently used drug to treat type II diabetic patients. Several clinical studies and observations have suggested that this molecule could harbor other beneficial effects such as anti-inflammatory, anti-oxidant and anti-cancer effects. For the past 15 years, increasing evidences have proposed an association between cancer and diabetes. In fact, it was demonstrated that the prevalence of colorectal cancer is increased in diabetic patients. Colorectal cancer is one of the most common types of cancers in the world. Studies have shown that colorectal cancer patients treated with metformin had a better prognosis due to the fact that metformin decreased cell proliferation, affected cellular viability and prevented metastasis occurrence. However the mechanism of action of metformin remains unclear. It is well known that metformin activates Adenosine Monophosphate activated Protein Kinase (AMPK) and studies have proven that AMPK acts as a tumor suppressor. A low grade inflammation is believed to participate in tumor formation and progression. Similarly to other inflammatory sites, monocytes migrate to a tumor and differentiate into macrophages depending on the local tissue environment, they are recognized as Tumor Associated Macrophages (TAMs). In the tumor, two different populations of TAMs arise; the pro-inflammatory macrophages (M1) and the anti-inflammatory macrophages (M2). The growth and expansion of a tumor are a complex phenomenon that involves genetic mutations as well as the perception of a multitude of messengers and cytokines. A growing body of evidences have demonstrated the involvement of reactive oxygen species (ROS), primarily generated by NADPH oxidase (NOX), in these phenomenon. Our aim was to study the effects of metformin on the behavior of immune cells especially macrophages as well as colon tumor cells, both constituting main cell components of a tumor. Firstly, we investigated the effect of metformin on the differentiation of freshly isolated human monocytes into macrophages, and its effect on ROS production by macrophages. Secondly, we examined the anti-cancer effects of metformin on the proliferation of human colon cancer cells and ROS production by these cells. Our results show that metformin selectively inhibited human monocyte’s differentiation into pro-inflammatory macrophages (M1) without inhibiting their differentiation into anti-inflammatory macrophages (M2). We also demonstrate that metformin inhibited ROS production by macrophages probably through the activation of AMPK. Indeed, we indicate that pharmacological activation of AMPK by AICAR, a known AMPK activator, decreased ROS production whereas the deletion of AMPK in mice dramatically enhanced ROS production in different types of immune cells. In addition, we confirm that metformin significantly repressed the proliferation of human colon cancer cells and it also showed a cytotoxic effect at high concentrations. We also found that metformin as well as AICAR and Compound 991, another known and very specific AMPK activator, decreased LPS induced ROS production by human colon cancer cells stipulating that AMPK might be involved in the process of ROS production. Moreover, we show that metformin suppressed LPS induced ROS production generated by NOX and those originating from the mitochondria which are the 2 main endogenous sources of ROS in a cell. Taken together, all our results suggest that metformin exhibits its anti-inflammatory, anti-oxidant and anti-cancer effects by inhibiting the differentiation of human monocytes into M1-macrophages while favoring their polarization into M2-macrophages, by repressing tumor cell proliferation and by decreasing ROS production by macrophages and tumor cells through the activation of AMPK.
submitted by JustLeafy2003 to copypasta [link] [comments]


2021.12.08 10:11 JerrieKim Unexpected boxing

submitted by JerrieKim to StreetMartialArts [link] [comments]


2021.12.08 10:11 regian24 The Secret Truth of all Life

The Secret Truth of all Life submitted by regian24 to oddlyspecific [link] [comments]


2021.12.08 10:11 jarellano89 What are these placements? I've never heard of them before, psyche, eros, etc..

What are these placements? I've never heard of them before, psyche, eros, etc.. submitted by jarellano89 to AskAstrologers [link] [comments]


2021.12.08 10:11 UmaTora Cat-safe Mistletoe for the Holidays!

Cat-safe Mistletoe for the Holidays! submitted by UmaTora to fountainpens [link] [comments]


2021.12.08 10:11 Better_Teaching6697 🎄 Cute Santa | 1000x potential 🚀 | Just Launched | Experienced Team | 7% DOGE rewards 🎁 | Anti-Whale | Dont Miss out !!!

What is Cute Santa?

Cute Santa is a reward token. Every 60 minutes, DOGE dividends will be sent to your wallet, if you hold at least 200,000 tokens. You can also manually claim your dividends in the main contract. Also each transaction you make will automatically claim your dividends. The longer you hold the more you earn!
A max wallet of 3% and max transaction of 1% allows us to prevent big wallets and dumps. The initial liquidity will be locked for several months into the deepest of the deepest locks and will be below 5 BNB so this token has the chance to go absolutely parabolic!

Tokenomics:
1,000,000,000 Total supply
3% max wallet to prevent whales
1% max tx to prevent dumps

Tax 10% for buy & sell:
7% in DOGE reward
1% to locked liquidity pool
2***% to marketing and buyback***
Slippage is ~ 10-12%

Links:
Contract: 0x5164a75e86403867d9863104b69c7d69c942d9dd
Buy Now: https://pancakeswap.finance/swap?outputCurrency=0x5164a75e86403867d9863104b69c7d69c942d9dd
Liquidty locked for 3 years: https://deeplock.io/lock/0xed767bB6A369E536F6c4A9F05dBBC01d94a744c6
submitted by Better_Teaching6697 to ico [link] [comments]


2021.12.08 10:11 Ok-Carpet2188 guys, is it possible for me to fill my hips? I need to have a wide hip by Friday, and my hip is about 80% full (this photo I got on pinterest) my hips have to look like this 😭 ‼️I should use affirmations like "my pelvis is wide" "my hip bone structure is wide"?

guys, is it possible for me to fill my hips? I need to have a wide hip by Friday, and my hip is about 80% full (this photo I got on pinterest) my hips have to look like this 😭 ‼️I should use affirmations like submitted by Ok-Carpet2188 to Subliminal [link] [comments]


2021.12.08 10:11 nclazrfpyt it’s anxiety inducing

it’s anxiety inducing submitted by nclazrfpyt to memes [link] [comments]


2021.12.08 10:11 Voider_13 关于微信传输接收图片速度过慢

这两天的微信呢 收突然不那么能行 收几个小姐妹发的小照片也得转圈一分半才能加载出 对面收我滴照片没有这个现象 这有可能是因特网上说的被晶哥重点关注了不
还有一个一直想问 微信的监管到底和qq是同步消息记录的不
求助了 比心
submitted by Voider_13 to China_irl [link] [comments]


2021.12.08 10:11 ShortAlgo $HPE Awaiting Short Signal. Stock Trading Ideas by UltraAlgo.com

$HPE Awaiting Short Signal. Stock Trading Ideas by UltraAlgo.com submitted by ShortAlgo to UltraAlgo [link] [comments]


2021.12.08 10:11 Violet_Specter 400% more work for 40% of the raise I asked for? Have fun finding a new team!

I've been working a remote data entry contracting job for around half a year now. It's been fine and laid-back, up until our old manager quit and a new one was installed around a month ago. He told me that my work quantity needed to be 2.5x than it currently was. That sucks, but I definitely felt I could do more, so I complied.
After 4 weeks of this, I figured that I deserved a raise for this new work (from $15/hr to $20/hr). I know this is a large jump, but keep in mind how much more work I've been doing now compared to my first 5 months of employment, especially without full-time benefits. On top of that, this new manager has been really flaky with communication, and doesn't respond to most of my messages or questions. Moreover, we've been receiving a few last-minute "emergency projects" thanks to the company's poor scheduling and planning. All of these seem like good reasons to ask for a raise that high.
I get into a meeting with a different manager (not mine) about the raise, and he says that the best he can do is $16/hr or $17/hr, which is 20%-40% of what I asked. I tell him "I'm not really happy with this, but I'll think on it more after the meeting." He then starts to condescend at me saying "most people aren't happy when they don't get what they ask for in life" and "I'm not in direct control of your pay rate, but even if I was, I wouldn't give you that much." As the meeting was wrapping up, he told us how he "appreciates my hard work."
And here comes the funny part! Literally on the same day after the meeting, the new manager tells us that we have a new quota, which is DOUBLE what I'm currently doing. In other words, it's 5x what I was doing before the new manager got installed. A few coworkers ask questions about it, and our manager basically tells us to suck it up.
400% more work for a 1-2 dollar raise? No thank you! Our productivity tracking system is really easy to game right now, so I'm currently coding a script to make it look like I'm doing enough work to meet the new quota. In reality, I'm going to be looking for a new job on company time. Once I find one, I'm giving a 0 day notice and leaving. Every coworker I've talked with on my team has made plans to quit soon. Here's to hoping it hits them hard!
submitted by Violet_Specter to antiwork [link] [comments]


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